What is the most commonly seen response in patients with severe sleep-disordered breathing following successful PAP titration?

The most commonly seen response in patients with severe sleep-disordered breathing following successful Positive Airway Pressure (PAP) titration is the rebound of REM (Rapid Eye Movement) and slow-wave sleep. This phenomenon occurs because PAP therapy alleviates airway obstruction, allowing for a restoration of normal sleep architecture that was previously disrupted by apneas and hypopneas.

In patients with sleep-disordered breathing, the quality and quantity of REM and deep sleep can be significantly reduced due to frequent awakenings and nighttime disturbances related to airway obstruction. Once effective PAP therapy is implemented, patients often experience a rebound effect where they can achieve deeper sleep stages, including REM and slow-wave sleep, which are critical for cognitive function, memory consolidation, and overall health.

While decreased daytime sleepiness might occur as a secondary benefit of improved sleep quality, and complete cessation of snoring is often an indicator of effective treatment, the rebound sleep stages specifically signify a restoration of the normal sleeping patterns that contribute to the patient's recovery. Increased appetite is generally not a direct response to effective PAP therapy and may even be contrary if improved sleep leads to better regulation of appetite-related hormones.